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Chapter 1 Looking through a Keyhole at the Tobacco Industry
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Chapter 1
Looking through a Keyhole at the Tobacco Industry

[The documents] may be evidence supporting a "whistle-blower's" claim that the tobacco company concealed from its customers and the American public the truth regarding the health hazards of tobacco products.
Federal Judge Harold Greene [Maddox v Williams 855 Fed. Supp. 406, at 414, 415 (D.D.C. 1994) ]


Introduction

Tobacco has been controversial at least since its introduction into Europe shortly after Columbus reported that North American natives used its dried leaves for pleasure (1, 2). The first medical report of tobacco's ill effects dates to 1665, when Samuel Pepys witnessed a Royal Society experiment in which a cat quickly expired when fed "a drop of distilled oil of tobacco." In 1791 the London physician John Hill reported cases in which use of snuff caused nasal cancers. Not until the late 1940s, however, did the modern scientific case that tobacco causes disease begin to accumulate rapidly. Epidemiological and experimental evidence that smoking causes cancer led to the "cancer scares" in the 1950s and, ultimately, to the 1964 Surgeon General's report on smoking and health, which concluded that smoking causes lung cancer (3). By responding to these challenges from the scientific community with aggressive legal, public relations, and political strategies, the tobacco industry has been largely successful in protecting its profits in spite of overwhelming scientific and medical evidence that tobacco products kill and disable hundreds of thousands of smokers and nonsmokers every year (1, 4).

What did the tobacco industry actually know about the addictive nature of nicotine and the dangers of smoking? How did the industry develop its successful legal, public relations, and political programs? Until now, the public's understanding of these questions has been based largely


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on observation of the industry's behavior and suppositions by a few journalists and public health professionals. This situation changed abruptly in mid-1994, when several thousand pages of internal documents from the Brown and Williamson Tobacco Corporation (B&W) and its parent, BAT Industries (formerly British American Tobacco) of the United Kingdom, became public. These documents reveal that the tobacco industry's public position on smoking and health has diverged dramatically not only from the generally accepted position of the scientific community but also from the results of its own internal research (see table 1.1, p. 15). While even these documents do not provide a complete picture, they offer a candid look at the tobacco industry's internal workings during the smoking and health "controversy" during the last half of the twentieth century.

BAT is the second-largest private cigarette manufacturer in the world. In 1992 the company sold 578 billion cigarettes (5), 10.7 percent of the total world output and more than were consumed in the entire US market that year (6). Its wholly owned US subsidiary, B&W, is now the third-largest cigarette maker in this country. Its US sales increased from about 10 percent of the market during the 1960s to about 18 percent in the 1970s, then fell back to about 10 percent in the 1980s (7). In 1994 it had an 18 percent share of the $48 billion US market, including the domestic cigarette business of American Brands, which B&W purchased in 1995 (8). B&W's domestic brands (before buying American Brands) include Kool, Viceroy, Raleigh, Barclay, Belair, Capri, Fact, and Richland, as well as GPC generic cigarettes.

The tobacco industry has used three primary arguments to prevent government regulation of its products and to defend itself in products liability lawsuits. First, tobacco companies have consistently claimed that there is no conclusive proof that smoking causes diseases such as cancer and heart disease. Second, tobacco companies have claimed that smoking is not addictive and that anyone who smokes makes a free choice to do so. And, finally, tobacco companies have claimed that they are committed to determining the scientific truth about the health effects of tobacco, both by conducting internal research and by funding external research.

These arguments have been essential to the industry's success in claiming that its products should not be subject to further government regulation and that it should not be held legally responsible for the health effects of its products. By refusing to admit that tobacco is addictive and that it causes disease, the tobacco industry has been able (so far) to


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resist efforts to regulate its products. In addition, the industry has been able to argue that cigarette smoking is a matter of "individual choice," thereby essentially blaming its customers for the diseases they contract by using tobacco products. Finally, the industry's stated willingness to support health-related research has added credibility to its claim that the health effects of smoking have not been scientifically proven, thus helping to allay public fears about its products.

This book analyzes internal documents from the files of Brown and Williamson—documents that were delivered to us, as well as other related documents that have been released to the public during the past year. The documents consist primarily of internal memoranda, letters, and research reports related to B&W and BAT. Many of them are marked "confidential" or "attorney work product," suggesting that the authors never expected them to be released outside the corporation, not even for legal proceedings. These documents demonstrate that the tobacco industry in general, and Brown and Williamson in particular, has engaged in deception of the public for at least thirty years. They show that other cigarette manufacturers participated in some of these activities. The documents are listed at the back of the book under the heading "List of Available Documents" and are cited in the text in curly braces (e.g., {1234.56}). Copies of the actual documents are deposited in the Archives and Special Collections Department of the Library at the University of California, San Francisco, where they are available to the public. They are also available over the Internet at World Wide Web address http://www.library.ucsf.edu/tobacco. The library also has a CD-ROM version of the Documents for sale.

In the documents nicotine is routinely seen as addicting and is always treated as the pharmacologically active agent in tobacco. There is no question that B&W and BAT regarded nicotine's pharmacological (drug) effects as key to the intended smoking experience. The documents also demonstrate that the tobacco industry's professed public-spirited approach to pursuing the truth about smoking and health has been a sham. Its purported willingness to engage in and disseminate health-related research was, in reality, always subservient to commercial and litigation considerations. Initially, the companies' researchers tried to discover the toxic elements in cigarette smoke so that a "safe" cigarette, which would deliver nicotine without also delivering the toxic substances, could be developed. When that objective proved to be unattainable, largely because of the number of toxins involved, decisions about health-related research passed almost exclusively to lawyers. The documents show that


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lawyers from B&W and other tobacco companies played a central role in research decisions, both within B&W and BAT and also in industry-sponsored research organizations.

The principal aim of this lawyer-controlled research effort was not to improve existing scientific or public understanding of the effects of smoking on health but, rather, to minimize the industry's exposure to litigation liability and additional government regulation. Where the goals of determining and disseminating the truth conflicted with the goal of minimizing B&W's liability, the latter consistently won out. In particular, even after B&W's research had shown that cigarettes cause disease and are addictive, under its lawyers' direction B&W sought to avoid generating any new results reconfirming that smoking causes disease or that nicotine is addictive. B&W sought to avoid affiliation with, or even knowledge of, such research results, for fear they could be used to show that B&W believed that smoking causes disease or that nicotine is addictive. B&W also sought to prevent the dissemination or disclosure of such results, either in court or in any public forum—apparently to the point of removing some relevant documents from its files and shipping them offshore.

Many of the documents are correspondence among company lawyers. In addition to providing insight into B&W and BAT's legal thinking, the lawyers effectively serve as candid witnesses for what the company actually believed at any particular time about disease causation and addiction. The lawyers appear to have accepted the causation and addiction hypotheses about smoking. The 1970s–1980s documents from lawyers specifying what could and could not be claimed in company public relations and advertising show that some lawyers regarded those hypotheses as so well established that they could not be denied directly without risking liability.

The documents show that by the 1960s the tobacco industry in general, and B&W and BAT in particular, had proven in its own laboratories that cigarette tar causes cancer in animals. In addition, by the early 1960s BAT's scientists (and B&W's lawyers) were acting on the assumption that nicotine is addictive. BAT responded by secretly attempting to create a "safe" cigarette that would minimize dangerous elements in the smoke while still delivering nicotine. Publicly, however, it maintained that cigarettes are neither harmful nor addictive. The tobacco industry's primary goal has been to continue as a large commercial enterprise by protecting itself from litigation and government regulation. To this day, despite overwhelming scientific evidence and official govern-


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ment reports, the tobacco industry contends that tobacco products are not addictive and do not cause any disease whatsoever.

B&W's And Bat's Corporate Structure

Brown and Williamson and its parent company, BAT Industries, have a close corporate relationship that has evolved over the years. The Brown and Williamson Tobacco Company was formed in 1906. It was purchased in 1927 by the British American Tobacco Company (BATCo), and its name was changed to the Brown and Williamson Tobacco Corporation {1006.01}. In 1976 BATCo merged with Tobacco Securities Trust to form BAT Industries.

BAT Industries is the parent company of many cigarette manufacturers throughout the world, including Brown and Williamson (US), BAT Cigarettenfabriken (Germany), Souza Cruz (Brazil), and British American Tobacco (which produces cigarettes in more than forty-five countries for domestic and export markets in Europe, Australia, Latin America, Asia, and Africa). In addition, BAT Industries is associated with Imasco in Canada, which is the parent company for Imperial Tobacco. BAT is also the parent company of several insurance and financial services, including Farmers Group (US), Eagle Star (UK), and Allied Dunbar (UK) (9).

Given B&W's status as a subsidiary of BAT, it was natural that the two companies would share information, not only about product development and sales and marketing strategies but also about their scientific research on the health dangers of cigarettes. As we discuss in chapter 2, B&W and the other domestic tobacco companies jointly formed an organization to study smoking and health issues in the mid-1950s, and British tobacco companies formed a similar group in England. In addition, as we discuss in chapter 3, BAT established research facilities (both internally and through contract laboratories) in Europe (England, Germany, and Switzerland) to study the health effects of smoking. The documents are replete with examples of information from all these research efforts, which was shared between B&W and BAT.

This sharing of information, although obviously of mutual benefit, also caused problems. As the evidence of the health dangers of smoking accumulated, B&W realized that it might become a defendant in products liability lawsuits by plaintiffs who claimed that their illnesses had been caused by cigarettes. Tobacco industry lawyers began to realize that the scientific research results that the companies were sharing could be


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extremely damaging if they became accessible to plaintiffs through discovery procedures. Tobacco companies in the United States were particularly concerned about the potential for lawsuits because products liability laws had been significantly strengthened during the 1960s. B&W therefore began to explore ways to avoid receiving unwanted information (i.e., information useful to a plaintiff) or to protect such information from discovery. In the United Kingdom, on the other hand, products liability laws have not historically been as strong as in the United States. BAT has therefore been more concerned about being dragged into a US lawsuit, because of its status as B&W's parent company, than about products liability suits in the United Kingdom (see chapter 7). A further problem for both companies was the possibility that statements attributable to subsidiary companies, including nontobacco companies, might be harmful to them in products liability litigation.

History Of The B&W Documents

On May 12, 1994, an unsolicited box of what appeared to be tobacco company documents was delivered to Professor Stanton Glantz at the University of California, San Francisco (UCSF). The documents in the box dated from the early 1950s to the early 1980s. They consisted primarily of confidential internal memoranda related to B&W and BAT. Many of the documents contained internal discussions of the tobacco industry's public relations and legal strategies over the years, and they were often labeled "confidential" or "privileged." The return address on the box was simply "Mr. Butts."

A few days earlier, US news media had started running stories based on what they said were internal documents from Brown and Williamson. In addition, internal documents related to Brown and Williamson were the subject of hearings held on June 23, 1994, before the US House of Representatives Subcommittee on Health and the Environment. The chairman and CEO of B&W, Thomas Sandefur, testified at these hearings and provided additional B&W documents to the subcommittee. In this book we analyze the documents delivered to Professor Glantz as well as the documents provided to the subcommittee, which were later released to the public, documents on nicotine research that B&W released to the press in May 1994 following a story in the New York Times (10), and documents obtained from the estate of a former BAT chief scientist.


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Brown and Williamson has claimed that some of the documents were stolen from the law firm of Wyatt, Tarrant and Combs in Louisville, Kentucky, by a former paralegal, Dr. Merrell Williams (11, 12). B&W had hired the Wyatt firm to sort and analyze millions of pages of B&W's internal communications, and Williams was one of the paralegals working on the project. This project involved reviewing about 8,600,000 pages of documents, 70,000 pages of which had been identified as "critical" {1002.01} (figure 1.1). Our analysis is based on roughly 10,000 pages, which represent only about 0.1 percent of the documents that were being reviewed.

Williams was hired by the Wyatt firm in 1988 but was laid off in 1992. The following year, Williams, a smoker, underwent major heart surgery. On July 9, 1993, he informed the Wyatt firm through an attorney that he had possession of some of the documents he had been hired to analyze. He returned the documents with a letter stating that his heart condition had been caused by the stress of reviewing the documents as well

Figure 1.1. The B&W document control project involved screening millions of pages of documents
{1002.01}. Our analysis is based on about 0.1 percent of the screened documents.


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as a lifetime of smoking Brown and Williamson brands of cigarettes, and he threatened to sue unless the Wyatt firm settled his claim (13). The Wyatt firm responded by filing a civil suit in the Circuit Court for Jefferson County, Kentucky, accusing Williams of stealing the documents. On January 7, 1994, Judge Thomas Wine issued an order prohibiting Williams from discussing or disseminating any of the information contained in the documents [Maddox v Williams , Jefferson Cir. Ct., Case No. 93 CI04806]. (On April 3, 1995, Judge Wine modified the order so that Williams could speak with his lawyer about the case. The modification was necessary, according to Judge Wine, because the documents in question were apparently part of the public domain in California, the Congress, and numerous news media, and because B&W had moved for contempt sanctions against Williams.)

On May 17, 1994, the Superior Court for the District of Columbia, at the request of B&W, issued subpoenas against several news agencies that had published or aired articles on some Brown and Williamson documents. The agencies receiving subpoenas were ABC, CBS, National Public Radio, the New York Times , the Washington Post , the Louisville Courier-Journal, USA Today, and the National Law Review . Subpoenas were also issued against Congressmen Henry Waxman (D-CA) and Ron Wyden (D-OR), who were members of the House Subcommittee on Health and the Environment. The purpose of the subpoenas, according to B&W, was to obtain copies of the documents so that B&W could determine whether they had been obtained in violation of the Kentucky court order against Merrell Williams.

The news organizations refused to turn over the documents in their possession on the grounds that they did not want to reveal the identity of a confidential source. The matter relating to the subpoenas issued against Congressmen Waxman and Wyden was removed to the US District Court for the District of Columbia on May 19, 1994. In a decision dated June 6, 1994, Judge Harold H. Greene quashed the subpoenas. Because the congressmen were using the documents in connection with a congressional investigation of B&W, the judge concluded, they were protected from the subpoenas under the Speech or Debate Clause of the US Constitution (Article I, Section 6) [Maddox v Williams , 855 F. Supp. 406 (D.D.C. 1994)]. That clause, which was designed to preserve legislative independence, provides that senators and representatives may not be questioned in any other place regarding speech or debate in either house of Congress. Despite this provision of the US Constitution, the subpoenas issued against Waxman and Wyden had directed them to submit in


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person to depositions in the law offices of Brown and Williamson's attorneys and to provide documents or copies to B&W from among the documents in the possession of Congress. According to Judge Greene, "It would be difficult to find orders that more directly impede the official responsibilities of the Congress and are thus in direct violation of the Speech or Debate Clause" [at 410, 411].

Following this decision, subpoenas issued by B&W were also quashed in three separate state court proceedings. On July 22, 1994 [in Maddox v Williams , No. 94-202], the Circuit Court for Arlington County, Virginia, quashed subpoenas issued to USA Today and one of its reporters. In November 1994 a Massachusetts court, citing "the public interest in the free flow of information," refused to enforce a subpoena issued by B&W against Professor Richard Daynard of Northeastern University School of Law [Robert J. Maddox v Merrell Williams , Civil Action No. 94-3389D]. Finally, on April 3, 1995, the Jefferson Circuit Court in Kentucky quashed subpoenas issued to the Louisville Courier-Journal and USA Today , stating that

despite B&W's contentions to the contrary, the production of the documents is to identify the source. While the attorney-client privilege may well be a bedrock of our judicial system, freedom of the press and its ability to protect sources of information is a pillar of our Federal Constitution [Maddox v Williams , Case No. 93 C104806].

In addition to the quashing of the subpoenas, other courts in other contexts have blocked B&W's attempts to suppress the documents. Thus, in April 1995 in an action by the state of Florida against several tobacco companies, the plaintiff introduced a set of B&W documents and the court denied defendants' motion to have the documents sealed, reasoning that

most, if not all, of the over 800 "stolen" documents filed with the Court as part of Plaintiffs' Request for Admissions were part of the public domain prior to being filed in this Court. These documents have been the subject of newspaper articles, television programs and Congressional hearings. ... To now seal the court files to protect the confidentiality of these documents would be futile [State of Florida v American Tobacco Co. (Cir. Ct. of 15th Judicial District for Palm Beach County, Florida, No. CL95-1466AO)].

During the summer of 1994 Professor Glantz placed the documents in the Archives and Special Collections Department of the UCSF Library, where they were made available to the public. On January 6, 1995, attorneys for a nonsmoker who had developed lung cancer and was suing Philip Morris Tobacco Company for damages attempted to convince a


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Mississippi judge to accept these documents into evidence [Butler v. Philip Morris , Civil Action No. 94-5-53, Cir. Ct., Jones County, Mississippi]. Twenty-five days later, on February 3, 1995, Brown and Williamson demanded that the University of California return the documents on the grounds that they were stolen. B&W also sent private investigators to the library to stake out the archives and to photograph people reading the documents. On February 14, 1995, B&W sued the University of California, demanding return of the documents and access to the library circulation records to learn who had read the documents [Brown & Williamson Tobacco Corp. v. Regents of the University of California (Super. Ct. for County of San Francisco, No. 967298)].

At a hearing on May 25, 1995, San Francisco Superior Court Judge Stuart Pollak denied B&W's attempt to "recover" the documents from the UCSF Library (11, 14). In reaching his decision, the judge noted the First Amendment concerns raised by B&W's request that the university be prevented from retaining or using the documents:

But the nature of what is being requested would in fact impinge upon public discussion, public study of this information, which has a bearing on all kinds of issues of public health, public law, documents which may be taken to suggest the advisability of legislation in all kinds of areas.

So, there is ... a very strong public interest in permitting this particular information, judging from what has been shown in the papers, as to what it concerns, permitting this information to remain available for use by the university or by others who may obtain it from the university [transcript of hearing, at 58, 59].

Again, as the Florida court had done, the San Francisco court noted that much, if not all, of the information in the documents had already been made available to the news media. "The genie is out of the bottle. These documents are out" [at 61].

The San Francisco court stayed its ruling for twenty days to give B&W time to appeal, thus leaving in effect a temporary restraining order against the university, which prevented it from allowing public access to the documents. B&W appealed to California's Court of Appeal and requested that the temporary restraining order be kept in force; the Court of Appeal denied this request without comment on June 22, 1995, as did the California Supreme Court on June 29, 1995. Thus, all the B&W documents used in the preparation of this book have been declared to be in the public domain, either by Congress or by the courts, and, in the case of some of the documents, by two or more authorities. At 12:01 A.M. PST on July 1, 1995, the University of California San Francisco Library


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and Center for Knowledge Management posted the documents on the Internet (http://www.library.ucsf.edu/tobacco).

Meanwhile, the authors of this book were working on their analysis of the documents and submitted a series of five related articles (which represent about 15 percent of the material in this book) to the Journal of the American Medical Association (JAMA) . After an extensive peer review, the editors of JAMA decided to devote most of the July 19, 1995, issue to these papers (15–19), together with an article detailing Brown and Williamson's reaction to the papers (11). In addition, JAMA took the unprecedented step of publishing an editorial, signed by the editors of JAMA and all the members of the Board of Trustees of the American Medical Association, demanding strong action to control the tobacco industry (20).

Publication of these papers attracted international attention, including that of President Bill Clinton, who read the papers and used them as part of his decision-making process to ask the federal Food and Drug Administration (FDA) to propose regulations of nicotine as an addictive drug and cigarettes and smokeless tobacco products as drug delivery devices (21). The fact that nicotine was in the product to affect the function of the body and that cigarettes could be engineered to control the dose of nicotine delivered got to the core of the issue of FDA jurisdiction to regulate cigarettes.

Limitations Of The Evidence

As noted above, the documents provide our first look—through a keyhole—at the inner workings of the tobacco industry during the crucial period in which the scientific case that smoking was addicting smokers and killing them solidified. Our view, however, is a limited one. One of its limitations has to do with the possibility of selection bias; that is, the documents may have been picked by a whistle-blower with an eye toward smoking guns. Another limitation, which shows up particularly in the legal and public relations aspects, is that we cannot always determine from the discussion in the documents whether particular ideas were actually carried out. In some cases the public record clearly shows that the contemplated actions were taken. In others—particularly when the industry's more sub rosa activities are being discussed—it is not obvious where the line between contemplated and actual action lies. As part of our analysis, we have tried to indicate which of these situations existed.


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In particular, the attorneys often discuss proposed courses of action, but the documents do not always clearly indicate which course of action the company ultimately chose. Lawyers by nature are asked to evaluate the legal risks of proposed courses of action, but their advice is not always followed. Nonetheless, we were struck by the active role the lawyers played, not just as advisers but also as managers; they often decided which research would be done or not done, who would be funded, and what public relations and political actions would be pursued. Generally speaking, the documents authored by attorneys did not outline possible courses of action or recommend which course to follow; instead, they strongly advocated that certain policies or actions be taken, some of which appear to raise serious ethical questions.

Another possible limitation is that the documents came from a single tobacco company and primarily reflect only the plans and actions of that company. Nevertheless, the documents include correspondence between B&W and other tobacco companies and trade organizations, as well as discussions of the actions of other companies and the industry in general. Many of the documents relate to industry-wide cooperation and reflect the views of participants, including lawyers, representing other companies and trade groups. In addition, other evidence—such as that presented in the Haines case, discussed in chapter 7—paints a similar picture of the actions of other tobacco companies. In any event, in our analysis of the documents, we have attempted to keep clear the distinction between the actions of B&W alone and the actions of the tobacco industry generally.

Despite these limitations, we are confident about the conclusions we draw from the documents. When lawyers are shown steering away from projects on the addictiveness or health effects of tobacco, we believe we can reasonably conclude that B&W and BAT knew that tobacco is addictive and causes disease; if it had been genuinely unconvinced of the dangers of smoking, then it would have had no concern that new research would provide ammunition for the enemy. The analogy would be to a criminal defense lawyer who doesn't ask the defendant whether he actually committed the crime because he does not want to be hampered in making his defense by embarrassing knowledge of the defendant's guilt. It will be easier to claim that the defendant is innocent, or even to put the defendant on the stand to testify to his innocence, if the lawyer does not ask the hard questions. The lawyers and scientists who wrote many of the documents were unusually candid in their remarks—possi-


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bly because they believed that the documents would be protected by the work product rule or attorney-client privilege, and therefore would never become public.

Conclusion

Although, as noted, this book analyzes only a tiny fraction of the documents that B&W had selected for review, the material in that small sample contains overwhelming evidence of the irresponsible and deceptive manner in which B&W has conducted its tobacco business. As will be seen in the following chapters, for more than thirty years B&W has been well aware of the addictive nature of cigarettes, and in the course of those years it has also learned of numerous health dangers of smoking. Yet, throughout this period, it chose to protect its business interests instead of the public health by consistently denying any such knowledge and by hiding adverse scientific evidence from the government and the public, using a wide assortment of scientific, legal, and political techniques.

The documents also demonstrate that B&W's conduct was representative of the tobacco industry generally. B&W acted in concert with the other domestic tobacco companies on numerous projects, the most important of which were specifically designed to prevent, or at least delay, public knowledge of the health dangers of smoking and to protect the tobacco companies from liability if that knowledge became public.

In his opinion quashing B&W subpoenas against Congressmen Waxman and Wyden, Judge Greene stated that it would be inappropriate to withhold the information in the documents from public scrutiny:

[The documents] may be evidence supporting a "whistle-blower's" claim that the tobacco company concealed from its customers and the American public the truth regarding the health hazards of tobacco products, and that he was merely bringing them to the attention of those who could deal with this menace. With the situation in that posture, to accept blindly the B&W "stolen goods" argument would be to set a precedent at odds with the law, with equity, and with the public interest.

If the B&W strategy were accepted, those seeking to bury their unlawful or potentially unlawful acts from consumers, from other members of the public, and from law enforcement or regulatory authorities could achieve that objective by a simple yet ingenious strategy: all that would need to be done would be to delay or confuse any charges of health hazard, fraud, corruption, overcharge, nuclear or chemical contamination, bribery, or other misdeeds, by focussing instead on inconvenient documentary evidence and labelling it


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as the product of theft, violation of proprietary information, interference with contracts, and the like. The result would be that even the most severe public health and safety dangers would be subordinated in litigation and in the public mind to the malefactor's tort or contract claims, real or fictitious.

The law does not support such a strategy or inversion of values. There is a constitutional right to inform the government of violations of federal laws—a right which under [United States Constitution] Article VI supersedes local tort or contract rights and protects the "informer" from retaliation [Maddox v Williams , 855 F. Supp. 406, at 414, 415 (D.D.C. 1994)].

In this spirit, we will describe in detail the contents of the Brown and Williamson documents and the story that they tell. There is little doubt that, had the information contained in the documents come to light at an earlier time, the history of tobacco control in the United States would have been vastly different.


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TABLE 1.1 PUBLIC VERSUS PRIVATE STATEMENTS MADE BY THE TOBACCO INDUSTRY

Nicotine and Addiction

Summary

By the early 1960s BAT and B&W had developed a sophisticated understanding of nicotine pharmacology and knew that nicotine was pharmacologically addictive. Publicly, however, the tobacco industry has maintained and continues to maintain that nicotine is not addictive. The scientific community was much slower to appreciate nicotine addiction: the Surgeon General did not conclude that nicotine was addictive until 1988 (22).

Surgeon General's
Reports

1964: "The tobacco habit should be characterized as an habituation rather than an addiction" (3).

1979: "[It] is no exaggeration to say that smoking is the prototypical substance-abuse dependency and that improved knowledge of this process holds great promise for prevention of risk" (23).

1988: "After carefully examining the available evidence, this Report concludes that:

• Cigarettes and other forms of tobacco are addicting.

• Nicotine is the drug in tobacco that causes addiction.

• The pharmacologic and behavioral processes that determine tobacco addiction are similar to those that determine addiction to drugs such as heroin and cocaine" (22, pp. 1–2).

B&W/BAT Research
Results

"There is increasing evidence that nicotine is the key factor in controlling, through the central nervous system, a number of beneficial effects of tobacco smoke, including its action in the presence of stress situations. In addition, the alkaloid [nicotine] appears to be intimately connected with the phenomena of tobacco habituation (tolerance) and/or addiction." From The Fate of Nicotine in the Body, a report describing results of contract research conducted for BAT by Battelle Memorial Institute in Geneva, Switzerland, 1963 {1200.20}.

 

"Chronic intake of nicotine tends to restore the normal physiological functioning of the endocrine system, so that ever-increasing dose levels of nicotine are necessary to maintain the desired action. ... This unconscious desire explains the addiction of the individual to nicotine." From "A Tentative Hypothesis on Nicotine Addiction," an essay written by scientists at Battelle and distributed to senior executives at BAT and B&W, 1963 {1200.01, p. 1}.

B&W/BAT Private Statements

"Moreover, nicotine is addictive. We are, then, in the business of selling nicotine, an addictive drug effective in the release of stress mechanisms." Addison Yeaman, vice president and general counsel, B&W, 1963 {1802.05, p. 4}.

Tobacco Industry's
Public Statements

"I do not believe that nicotine is addictive ... nicotine is a very important constituent in the cigarette smoke for taste." Thomas Sandefur, chairman and CEO, B&W, testifying before the Health and Environment Subcommittee, Energy and Commerce Committee, House of Representatives, June 23, 1994 (24).

(Table continued on next page)


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TABLE 1.1 (continued )

Low-Tar, Low-Nicotine Cigarettes and Smoker Compensation

Summary

Smokers compensate for the lack of nicotine in low-tar, low-nicotine cigarettes by puffing more frequently, by increasing the depth or duration of smoke inhalation, by smoking more cigarettes per day, and by smoking cigarettes to a shorter butt length. This means that smokers of low-tar, low-nicotine cigarettes are exposed to more "tar" and other harmful chemicals than would be indicated by an analysis of the cigarette smoke. This phenomenon, known as smoker compensation, was acknowledged internally in the tobacco industry by the early 1970s but was not appreciated in the scientific community until the 1980s.

Surgeon General's
Reports

1966: "The preponderance of scientific evidence strongly suggests that the lower the 'tar' and nicotine content of cigarette smoke, the less harmful would be the effect" (25).

1979: "[The public] should be warned that, in shifting to a less hazardous cigarette, they may in fact increase their hazard if they begin smoking more cigarettes or inhaling more deeply" (23).

1981: "Smokers may increase the number of cigarettes they smoke and inhale more deeply when they switch to lower yield cigarettes. Compensatory behavior may negate any advantage of the lower yield product or even increase the health risk" (25).

B&W/BAT Research Results

"[W]hatever the characteristics of cigarettes as determined by smoking machines, the smoker adjusts his pattern to deliver his own nicotine requirements." Minutes from BAT's research conference held in Duck Key, Florida, 1974, taken by SJG [S. J. Green of BAT R&D] {1125.01, p. 2}.

 

"Compensation study conducted by Imperial Tobacco Co., a BATCo affiliate, [shows that a smoker] adjusts his smoking habits when smoking cigarettes with low nicotine and TPM [total particulate matter] to duplicate his normal cigarette nicotine intake." From document titled "Chronology of Brown & Williamson Smoking and Health Research," regarding research conducted in 1975. Chronology dated 1988 {1006.01, p. 27}.

B&W/BAT Internal Statements

"In most cases, however, the smoker of a filter cigarette was getting as much or more nicotine and tar as he would have gotten from a regular cigarette." Ernest Pepples, vice president and general counsel, B&W, 1976 {2205.01, p. 2}.

Tobacco Industry's
Public Statements

"All the fuss about smoking got me to thinking I'd either quit or smoke True. I smoke True." Advertisement for Lorillard's True cigarettes in Ms. magazine, October 1975.

"I like to smoke, and what I like is a cigarette that isn't timid on taste. But I'm not living in some ivory tower. I hear the things being said against high-tar smoking as well as the next guy. And so I started looking. For a low-tar smoke that had some honest-to-goodness taste. Advertisement for Vantage cigarettes in Time magazine, November 9, 1977, pp. 86–87.

(Table continued on next page)


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TABLE 1.1 (continued )

Role of the Tobacco Industry's Research Committee/Council for Tobacco Research

Summary

The Tobacco Industry Research Committee (TIRC), later renamed the Council for Tobacco Research-U.S.A., Inc. (CTR), was created by US tobacco companies in 1954. The tobacco industry has publicly claimed that TIRC/CTR is an independent organization that funds unbiased research into the health effects of smoking. Internally, however, tobacco industry representatives have stated that TIRC/CTR was created for public relations purposes, and that it later fulfilled political and legal roles.

B&W/BAT Private Statements

"Originally, CTR was organized as a public relations effort. ... The research of CTR also discharged a legal responsibility. ... Finally the industry research effort has included special projects designed to find scientists and medical doctors who might serve as industry witnesses in lawsuits or in a legislative forum." Ernest Pepples, vice president and general counsel, B&W, 1978 {2010.02, p. 2}.

Tobacco Industry's
Public Statements

"From the outset, the Tobacco Industry Research Committee has made clear that the object of its research program is to encourage scientific study for facts about tobacco use and health. Its position is that research will help provide the knowledge about lung cancer and heart disease for a full evaluation of all factors being studied in connection with these diseases." Public relations document, circa 1963 {1903.03, p. 1}.

 

"The Council for Tobacco Research-U.S.A., Inc., is the sponsoring agency of a program of research into questions of tobacco use and health. ... The Council awards research grants to independent scientists who are assured complete scientific freedom in conducting their studies. Grantees alone are responsible for reporting or publishing their findings in the accepted scientific manner—through medical and scientific journals and societies" (26).

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TABLE 1.1 (continued )

Smoking and Disease, 1960's

Summary

By the early 1960s the scientific community had determined that smoking is causally related to lung cancer and probably related to heart disease. Results from tobacco industry laboratories supported these conclusions, but the tobacco industry publicly denied that the links had been proven.

Surgeon General's
Reports

1964: "Cigarette smoking is causally related to lung cancer in men; the magnitude of the effect of cigarette smoking far outweighs all other factors. The data for women, though less extensive, point in the same direction" (3).

"Cigarette smoking is the most important of the causes of chronic bronchitis in the United States, and increases the risk of dying from chronic bronchitis" (3).

"Male cigarette smokers have a higher death rate from coronary artery disease than non-smoking males, but it is not clear that the association has causal significance" (3).

"Cigarette smoking is a significant factor in the causation of cancer of the larynx [and] an association exists between cigarette smoking and cancer of the urinary bladder in men" (3).

B&W/BAT Research
Results

"Scientists with whom I talked [at BAT's laboratories in Great Britian] were unanimous in their opinion that smoke is weakly carcinogenic under certain conditions and that efforts should be made to reduce this activity." Dr. R. B. Griffith, head of R&D, B&W, 1965 {1105.01, p. 2}.

B&W/BAT Private Statements

"At the best, the probabilities are that some combination of constituents of smoke will be found conducive to the onset of cancer or to create an environment in which cancer is more likely to occur." Addison Yeaman, vice president and general counsel, B&W, 1963 {1802.05, p. 1}.

Tobacco Industry's
Public Statements

"The smoking of tobacco continues to be one of the subjects requiring study in the lung cancer problem, as do many other agents and influences in modern living. Science does not yet know enough about any suspected factors to judge whether they may operate alone, whether they may operate in conjunction with others, or whether they may affect or be affected by factors of whose existence science is not yet aware." Public relations document, circa 1967 {1903.03, p. 3}.

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TABLE 1.1 (continued )

Smoking and Disease, 1970s

Summary

Throughout the 1970s B&W and BAT (and probably the other tobacco companies as well) privately engaged in a massive research campaign to identify and remove any toxic compounds identified in tobacco smoke. Privately, B&W and BAT scientists concluded there was no scientific controversy about the dangers of smoking. Their goal was to create a "safe" cigarette. However, their research showed that it would be very difficult to remove all the different toxic compounds in tobacco smoke. Publicly, the industry continued to deny that smoking had been proven harmful to health.

Surgeon General's
Reports

1972: "Tobacco use is associated with increased risk of coronary heart disease; cerebrovascular disease (stroke); aortic aneurysm; peripheral vascular disease; chronic obstructive bronchopulmonary disease (COPD); cancers of the lung, lip, larynx, oral cavity, esophagus, urinary bladder, and pancreas; and gastrointestinal disorders such as peptic ulcer disease. In addition, maternal smoking during pregnancy retards fetal growth" (27).

B&W/BAT Research
Results

"Carbon monoxide [CO] will become increasingly regarded as a serious health hazard for smokers. The methods of control available are ventilation, diffusion and the choice of smoking materials. But the inverse relationship of polycyclic aromatics and carbon monoxide is still observed, e.g. lithium hydroxide reduces CO substantially but is coupled with an increase in tumorigenic activity." Minutes from BAT research conference held in Duck Key, Florida, 1974, taken by S. J. Green of BAT R&D {1125.01, p. 3}.

B&W/BAT Private Statements

"There has been no change in the scientific basis for the case against smoking. Additional evidence of smoke-dose related incidence of some diseases associated with smoking has been published. But generally this has long ceased to be an area for scientific controversy." Minutes from BAT research conference held in Sydney, Australia, 1978, taken by S. J. Green of BAT R&D {1174.01, p. 1}.

Tobacco Industry's
Public Statements

"Taking all the above into consideration, we believe there is sound evidence to conclude that the statement 'cigarettes cause cancer' is not a statement of fact but merely an hypothesis " [emphasis in original]. B&W public relations document, 1971 {2110.06, p. 10}.

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20
 

TABLE 1.1 (continued )

Smoking and Disease, 1980s

Summary

B&W and BAT continued their efforts to develop a "safer" cigarette during the 1980s. The focus of their research was on minimizing the "biological activity," or carcinogenic potential, of their products. Unfortunately, that proved more difficult than expected. In addition, as the scientific community noted, even if less carcinogenic cigarettes could be designed, these cigarettes would still cause some cancer, as well as heart disease and other noncancer diseases.

Surgeon General's
Reports

1981: "Smoking cigarettes with lower yields of 'tar' and nicotine reduces the risk of lung cancer and, to some extent, improves the smoker's chance for longer life, provided there is no compensatory increase in the amount smoked. However, the benefits are minimal in comparison with giving up cigarettes entirely" (25).

1989: "Smoking is responsible for more than one of every six deaths in the United States. Smoking remains the single most important preventable cause of death in our society" (28).

B&W/BAT Research
Results

"Cigarette brands can be readily distinguished [in terms of mutagenicity as judged by an Ames test]. This is in contrast with the earlier mouse skin painting results. An unfortunate side-effect is that the sensitivity increases the probability of an Ames League Table [which would rank different brands of cigarettes according to mutagenicity using the Ames test] appearing. A further unfortunate examination is that, to date, it is not uncommon for BAT brands to have a higher result [i.e., greater mutagenicity] than those from the opposition." Minutes from BAT biological conference held in Southampton, England, 1984, author unknown {1181.06, p. 1}.

B&W/BAT Private Statements

"Despite intense research over the past 25 years, the biological activity of smoke remains a major challenge. In particular, it is not known in quantitative terms whether the smoke from modern low and ultra-low delivery products has a lower specific biological activity than that from previous high delivery products. Nor is it clearly established ... what are the main factors that influence biological [carcinogenic] activity." Minutes from BAT research conference held in Montebello, Canada, 1982, prepared by L. C. F. Blackman of BAT R&D {1179.01, p. 4}.

Tobacco Industry's
Public Statements

"Cigarette smoking has not been scientifically established to be a cause of chronic diseases, such as cancer, cardiovascular disease, or emphysema. Nor has it been shown to affect pregnancy outcome adversely." Sheldon Sommers, M.D., scientific director of the CTR in congressional testimony, March 1983 (29).

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21
 

TABLE 1.1 (continued )

Mouse Skin–Painting Experiments

Summary

Both the tobacco industry and the general scientific community have relied on mouse skin–painting experiments to evaluate the carcinogenicity of elements in tobacco smoke. Publicly, however, the tobacco industry has criticized the validity of these tests.

Surgeon General's
Reports

1964: "[I]nduction of cancer by a compound in one species does not prove that the test compound would be carcinogenic in another species under similar circumstances. Therefore, tests for carcinogenicity in animals can provide only supporting evidence for the carcinogenicity of a given compound or material in man. Nevertheless, any agent that can produce cancer in an animal is suspected of being carcinogenic in man also" (3).

 

"Almost every species that has been adequately tested has proved to be susceptible to the effect of certain polycyclic aromatic hydrocarbons identified in cigarette smoke and designated as carcinogenic on the basis of tests in rodents. Therefore, one can reasonably postulate that the same polycyclic hydrocarbons may also be carcinogenic in one or more tissues of man with which they come in contact" (3).

B&W/BAT Research
Results

"Studies in instant [fresh] condensate are showing a biological activity towards mouse-skin of the same order as that of stale condensate, suggesting that the biological activity is not time-dependent. The clear possibility of producing cigarettes with reduced mouse-skin biological activity therefore becomes of greater importance and a research solution to the whole problem is more likely." Minutes from BAT research conference held in Hilton Head Island, South Carolina, 1968, prepared by S. J. Green of BAT R&D {112.01, p. 1}.

 

"The meeting agreed that it would be worthwhile to make a cigarette with lower biological activity on mouse skin painting, provided this did not adversely affect the position with respect to irritation and other factors. It was recognized that this implied certain assumptions about the relevance of mouse skin painting." Minutes from BAT research conference held in Montreal, Canada, 1967, author unknown {1165.02, p. 3}.

B&W/BAT Private Statements

"Historically, bioassay experiments were undertaken by the Industry with the object of clarifying the role of smoke constituents in pulmonary carcinogenesis. The most widely used of these methods [was] mouse-skin painting. ... (a) In the foreseeable future, say five years, mouse-skin painting would remain as the ultimate court of appeal on carcinogenic effects." Minutes from BAT research conference held in Kronberg, Germany, 1969, prepared by S. J. Green of BAT R&D {1169.01, pp. 2–4}.

Tobacco Industry's
Public Statements

"Much of the experimental work involves mouse-painting or animal smoke inhalation experiments. ... [T ]hese condensates are artificially produced under laboratory conditions and, as such, have little, if any, relation to cigarette smoke as it reaches the smoker. Further, the results obtained on the skin of mice should not be extrapolated to the lung tissue of the mouse, or to any other animal species. Certainly such skin results should not be extrapolated to the human lung." B&W public relations document, 1971 [emphasis in original] {2110.06, pp. 6–7}.

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TABLE 1.1 (continued )

Environmental Tobacco Smoke (ETS)

Summary

During the 1970s and 1980s scientific evidence began to suggest that exposure to environmental tobacco smoke could cause adverse health effects, such as lung cancer and cardiovascular disease, in nonsmokers. B&W and BAT responded by privately attempting to create a product that produced less hazardous sidestream smoke. Publicly, however, the industry has denied that passive smoking has been proven harmful to health.

Surgeon General's
Reports

1972: "1. An atmosphere contaminated with tobacco smoke can contribute to the discomfort of many individuals.

2. The level of carbon monoxide attained in experiments using rooms filled with tobacco smoke had been shown to be equal, and at times to exceed, the legal limits for maximum air pollution permitted for ambient air quality. ...

3. Other components of tobacco smoke, such as particulate matter and the oxides of nitrogen, have been shown in various concentrations to affect adversely animal pulmonary and cardiac structure and function. The extent of the contribution of these substances to illness in humans exposed to the concentrations present in an atmosphere contaminated with tobacco smoke is not presently known" (27).

 

1982: Epidemiologic studies on ETS and lung cancer "raise the concern that involuntary smoking may pose a carcinogenic risk to the nonsmoker" (30).

 

1986: "This review leads to three major conclusions:

 

1. Involuntary smoking is a cause of disease, including lung cancer, in healthy nonsmokers.

 

2. The children of parents who smoke compared with the children of nonsmoking parents have an increased frequency of respiratory infections, increased respiratory symptoms, and slightly smaller rates of increase in lung function as the lung matures.

 

3. The simple separation of smokers and nonsmokers within the same air space may reduce, but does not eliminate, the exposure of nonsmokers to environmental tobacco smoke" (31).

B&W/BAT Research
Results

"SIDESTREAM RESEARCH AND DEVELOPMENT. Strategic objectives remain as follows:

1. Develop cigarettes with reduced sidestream yields and/or reduced odour and irritation.

2. Conduct research to anticipate and refute claims about the health effects of passive smoking."

 

Summary of BAT Group Research and Development Centre Activities on Sidestream, Psychology, circa 1984 {1181.12, p. 1}.

B&W/BAT Private Statements

"We must get hard data both to help counter anti-smoking attacks, and to support the design of future products. ... We should keep within BAT:

 

i) animal results on sidestream activity

 

ii) thoughts on the biological activity [carcinogenicity] of sidestream [smoke]

 

iii) research findings on the consumer annoyance aspects of environmental [tobacco] smoke—since these have potential commercial value."

 

Minutes from BAT research conference held in Montebello, Canada, 1982, prepared by L. C. F. Blackman of BAT R&D {1179.01, p. 7}.

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23
 

TABLE 1.1 (continued )

Environmental Tobacco Smoke (ETS)

Tobacco Industry's
Public Statements

"[E]vidence relating ETS to health effects is scanty, contradictory and often fundamentally flawed. ... [M]ore and better research needs to be done" (32, p. 1).

"[E]xposure to environmental tobacco smoke has not been shown to cause lung cancer in nonsmokers. ... [S]uch exposure has not been shown to impair the respiratory or cardiovascular health of nonsmoking adults or children, or to exacerbate preexisting disease in these groups, or to cause 'allergic' symptoms on a physiological basis" (32, p. 51).

SOURCE : S. A. Glantz, D. E. Barnes, L. Bero, P. Hanauer, and J. Slade, Looking through a keyhole at the tobacco industry: The Brown and Williamson documents, JAMA 1995;274:219–224.

References

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11. Graham T. The Brown and Williamson documents: The company's response. JAMA 1995;274:254–255.

12. Orey M. A mole's tale. The American Lawyer 1995 July/August:86–92.

13. Shapiro E. The insider who copied tobacco firm's secrets. Wall Street Journal 1994 June 20:B1.

14. Siegel M. University counsel battles Brown and Williamson over tobacco documents. The American Lawyer 1995 July/August:48.

15. Glantz SA, Barnes DE, Bero L, Hanauer P, Slade J. Looking through a keyhole at the tobacco industry: The Brown and Williamson documents. JAMA 1995;274:219–224.

16. Slade J, Bero L, Hanauer P, Barnes DE, Glantz SA. Nicotine and addiction: The Brown and Williamson documents. JAMA 1995;274:225–233.

17. Hanauer P, Slade J, Barnes DE, Bero L, Glantz SA. Lawyer control of internal scientific research to avoid products liability lawsuits: The Brown and Williamson documents. JAMA 1995;274:234–240.


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18. Bero L, Barnes DE, Hanauer P, Slade J, Glantz SA. Lawyer control of the tobacco industry's external research program: The Brown and Williamson documents. JAMA 1995;274:241–247.

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20. Todd JS, Rennie D, McAfee RE, et al. The Brown and Williamson documents: Where do we go from here? (editorial). JAMA 1995;274:256–259.

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22. USDHHS. The Health Consequences of Smoking: Nicotine Addiction. A Report of the Surgeon General. US Department of Health and Human Services, Public Health Service, Centers for Disease Control, Center for Health Promotion and Education, Office on Smoking and Health, 1988. DHHS Publication No. (CDC) 88-8406.

23. USDHEW. Smoking and Health. A Report of the Surgeon General. US Department of Health, Education and Welfare, Public Health Service, Office of the Assistant Secretary for Health, Office on Smoking and Health, 1979. DHEW Publication No. (PHS) 79-50066.

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28. USDHHS. Reducing the Health Consequences of Smoking: 25 Years of Progress. US Department of Health and Human Services, Public Health Service, Centers for Disease Control, Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, 1989. DHHS Publication No. (CDC) 89-8411.

29. Wolinsky H. When researchers accept funding from the tobacco industry, do ethics go up in smoke? NY State J Med 1985;85(7):451–455.

30. USDHHS. The Health Consequences of Smoking: Cancer. A Report of the Surgeon General. US Department of Health and Human Services, Public Health Service, Office on Smoking and Health, 1982. DHHS Publication No. (PHS) 82-50179.

31. USDHHS. The Health Consequences of Involuntary Smoking. A Report of the Surgeon General. US Department of Health and Human Services, Public Health Service, Centers for Disease Control, 1986. DHHS Publication No. (CDC) 87-8398.

32. Tobacco Institute. Tobacco Smoke and the Nonsmoker: Scientific Integrity at the Crossroads. Washington, DC: Tobacco Institute, 1986.


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